CSF biomarkers for mild cognitive impairment
نویسندگان
چکیده
منابع مشابه
CSF tau and β-amyloid as biomarkers for mild cognitive impairment
Early diagnosis of Alzheimer s disease (AD) is relevant in order to initiate symptomatic treatment with antidementia drugs. This will be of greater significance if the drugs aimed at slowing down the degenerative process (secondary prevention) prove to affect AD pathology and are clinically effective, such as γ-secretase inhibitors. However, there is currently no clinical assessment to differen...
متن کاملCSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
CONTEXT Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. OBJECTIVE To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (Abeta42), total tau protein (T-tau), and tau phosphorylated at...
متن کاملDifferential White Matter Connectivity in Early Mild Cognitive Impairment According to CSF Biomarkers
Mild cognitive impairment (MCI) is a heterogeneous group and certain MCI subsets eventually convert to dementia. Cerebrospinal fluid (CSF) biomarkers are known to predict this conversion. We sought evidence for the differences in white matter connectivity between early amnestic MCI (EMCI) subgroups according to a CSF phosphorylated tau181p/amyloid beta1-42 ratio of 0.10. From the Alzheimer's Di...
متن کاملCombined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease.
This study aimed to identify preclinical Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) using measurements of both regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) biomarkers. Baseline rCBF assessments ((133)Xe method) were performed in 70 patients with MCI who were cognitively stable for 4-6 years, 69 patients with MCI who subsequently developed AD, ...
متن کاملCorrelates of Subjective and Mild Cognitive Impairment: Depressive Symptoms and CSF Biomarkers
AIMS To improve early diagnosis of dementia disease, this study investigates correlates of cognitive complaints and cognitive test performance in patients with subjective (SCI) and mild (MCI) cognitive impairment. METHODS Seventy patients from a memory clinic, aged 45-79, with a score of 2 (n = 23) or 3 (n = 47) on the Global Deterioration Scale, were included. CSF biomarkers [Aβ42, total tau...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2004
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.2004.01368.x